Metformin
A long-used prescription medication that improves insulin sensitivity. Common in PMOS care, especially around conception.
Metformin is a prescription medication that lowers the amount of glucose the liver produces and improves how cells respond to insulin. It is one of the longest-used interventions in PMOS, with decades of clinical experience behind it.
In PMOS it is used to address the insulin side of the condition, and it is commonly part of care for people preparing to conceive when insulin resistance is in the picture. Improving insulin sensitivity can, in turn, support more regular ovulation in some people.
Gastrointestinal side effects (nausea, loose stools) are common in the first weeks and usually settle, often helped by starting low and going slow or using an extended-release form. Like all prescription options, metformin is a clinician-led decision that follows from the foundational steps rather than replacing them.